If only waived data is available for the substance, following justifications for data-waiving can be displayed in the Brief Profile: Some endpoints are not included in the Brief Profile due to the use of free text and/or complex field(s) in the reporting of information, which cannot be easily summarised by an automatic algorithm. The goal of CLP is to make sure that hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through a system of classifying and labelling of chemicals. If so, the data provided is not processed for the Brief Profile. If more than one value is found for this section, the range of min-max values will be displayed here. Trade names gives all public trade names submitted to ECHA in REACH registrations. Log Pow (Log Kow) provides substance information on the partition coefficient type Log Pow (Log Kow) at a temperature measured in °C. This section summarises the water solubility values from all registered dossiers for the substance. the minimum numerical value associated with the highest priority picklist item. This section summarises the values related to adsorption/desorption from all registered dossiers for the substance. EC10 / LC10 or NOEC for freshwater invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater invertebrates or the no observed effect concentration for freshwater invertebrates. [, Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Registrants can register their substance’s oxidising properties as: Note: Registrants can also select ‘other’ as the oxidising value for their substance. The CoRAP list includes substances that could pose a risk to human health or the environment and whose (potentially hazardous) properties are to be evaluated by the Member States in the next three years. Within each of these categories, data is prioritised further by duration (in hours), with longer prioritised over shorter. Contact us to learn more about these and other features. Melting/freezing point at 101 325 Pa provides information on the substance melting/freezing point in °C at a pressure of 101 325 Pa. Note: Registrants can also select ‘other’ as the type of density. This section summarises the values related to biodegradation in soil from all registered dossiers for the substance. ECHA has no public registered data on the use of this substance in activities or processes at the workplace. Solubility in organic solvents / fat solubility. Hazard to aquatic organisms provides information on the substance’s hazard assessment conclusion regarding aquatic organisms. This substance is used at industrial sites and in manufacturing. Precautionary measures and guidance on safe use concern the use and handling of the specific substance, not of the presence of the substance in other articles or mixtures. Due to the quantity of information and the number of chemicals, the Brief Profile is automatically generated based on the information available and is not manually verified. BOD5/COD ratio provides substance information on the substance’s BOD5/COD ratio values displayed in O2 (milli)gram per gram test material. Registrants can register their substance oxidising properties as: This section summarises the oxidation reduction potential values from all registered dossiers for the substance. Oral route provides substance information on the substance’s acute toxicity via the oral route. This section summarises the values related to toxicity to microorganisms from all registered dossiers for the substance. If so, the data provided is not processed in the Brief Profile. Later work showed that pimelic acid supplementation Therefore this does not constitute official and legally binding information. In IUPAC nomenclature, prefixes, suffixes and infixes are used to describe the type and position of functional groups in the substance. If so, the data provided is not processed for the Brief Profile. Displayed is the most conservative of the prioritised value(s). H Pa m3/mol provides substance information on the substance’s Henry’s Law Constant in Pa m3/mol at a temperature measured in °C and the atmospheric pressure measured in Pascal. Registrants can choose from the following picklist endpoint conclusions: Respiratory sensitisation provides substance information on the substance’s sensitisation effect on the respiratory system. If so, the data provided is not processed for the Brief Profile. For accuracy reasons, substance manufacturers and importers are responsible for consulting official sources. This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only. If you have any comments or suggestions, please contact ECHA using our contact form. Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Labeling and inhibitor studies show that pimelic acid is made by the fatty acid synthetic pathway. The purpose of the information provided under this section is to highlight in a readable format the substance hazardousness. This section displays the values related to repeated dose toxicity from all registered dossiers for the substance. If so, the data provided is not processed for the Brief Profile. More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header. Precautions for using this substance have been recommended by its registrants under REACH, as follows: When handling this substance: wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray. Values are displayed in milligram per litre. The molecular formula identifies each type of element by its chemical symbol and identifies the number of atoms of each element found in one discrete molecule of the substance. This section summarises the values related to the screening tests for biodegradation in water from all registered dossiers for the substance. Registrant can provide information on eye exposure as mentioned above for ‘Data for workers – eye exposure.’. Note: Registrants can also select ‘other’ as the picklist conclusion. The Restriction list describes the conditions for the manufacture, placing on the market or use of certain substances, either on their own or in mixtures or articles. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). level’ as the dose descriptor. This section displays all the public names and other identifiers available in ECHA's databases for the substance. LC50 for freshwater fish provides substance information on the substance’s lethal concentration for 50% of the freshwater fish in the test, displayed in milligram per litre. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data for calculating the ’total tonnage’ band is extracted from REACH registered dossiers for the last year reported on the tonnage manufactured or imported, unless the tonnage band has been claimed confidential. Sed elementum odio augue, eget iaculis lorem faucibus vel. REACH registration dossiers notifications. pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C. After evaluation, proposals may be made for further regulatory action regarding the substance. bp 100 272°; bp 50 251.5°; bp 15 223°; bp 10 212°. LC50 for marine water algae provides substance information on the substance’s lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre. REACH registration dossiers have greater data requirements (support studies) than notifications under CLP. If the substance has no EC number attributed, ECHA will attribute a list number. Data is generally displayed in milligrams per kilogram bodyweight per day. Also, if the registrant selects the ‘mg/100 g solvent’; ‘g/kg solvent’; ‘ppb’; ‘vol%’ and ‘other’ as a unit of measure, the data provided will not be processed for the Brief Profile. By summarising this information in a single page, ECHA aims to make this information accessible in a user-friendly way in line with the Agency’s goals and standards. Y is the check-digit calculated in accordance with the 10-digit ISBN method. Our clients have developed successful models for drug targets, side effects, toxicity, and drug-drug interactions. Molecular Weight 160.17 . Data is generally displayed in milligram per kilo bodyweight. This section summarises the partition coefficient values from all registered dossiers for the substance. Note: Registrants can also select ‘BMD’, ‘BMC’, ‘dose level’ and ‘conc. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). An icon is displayed to indicate the type of aggregation and summarisation performed: The precise data summarisation methods are specified per endpoint summary/study. Therefore, data has to fit the format and aggregation logic that is used for the Brief Profile. All Rights Reserved. The CLP regulatory processes identified for the Brief Profile are: The BPR (528/2012) entered into force on 1 September 2013. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre. Nulla pulvinar vitae nunc vitae sagittis. If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method). Free pimelic acid is a key intermediate of biotin synthesis in Bacillus subtilis. If such information is available in ECHA’s database and is it not claimed confidential, the molecular formula and molecular structure will be displayed here. Classifications under REACH have to be supported by data (support studies). Solubility in water: 50g/L (20°C). Within the context of REACH, impurities are unintended constituents present in a substance as manufactured. The aim is to display the lowest values reported as causing the most adverse effects, and hence the broadest possible safety margins for the substance. Articles of Pimelic acid are included as well. Dissociating Properties provides substance information by picklist values: Dissociation Constant provides numerical substance information on the substance’s dissociation constant values at a temperature measured in °C. More detailed information is available in the dossiers. Values are generally displayed in milligram per litre. Pimelic acid is the organic compound with the formula HO 2 C(CH 2) 5 CO 2 H. Derivatives of pimelic acid are involved in the biosynthesis of the amino acid called lysine.Pimelic acid is one methylene longer than a related dicarboxylic acid, adipic acid, a precursor to many polyesters and polyamides.. Pimelic acid has been synthesized from cyclohexanone and from salicylic acid. In this case, the preferred CAS number is displayed first. The Index number is the identification code given to substances in Part 3 of Annex VI to the CLP Regulation ((EC) No 1272/2008). 1.6), oxidising: maximum burning rate equal or higher than reference mixture, oxidising: vigorous reaction in preliminary test. Autoflammability / Self-ignition provides substance information on the substance’s self-ignition temperature in °C  at a pressure measured in Pascal. 1). test not applicable because organic peroxide. These substances cannot be placed on the market or used after a given date, unless an authorisation is granted for their specific use, or the use is exempted from authorisation. Note: Registrants can also select ‘other’ as the test species. Phototransformation in water provides information on the substance’s phototransformation in water in seconds/minutes/hours/days/weeks/months/years. Thirdly the display of data is prioritised by units. Pimelic acid has been synthesized from cyclohexanone and from salicylic acid. No or insufficient data available at present, Hazard related to composition of atmosphere identified, No potential to cause toxic effects if accumulated (in higher organisms) via the food chain, bw/day (mg/kg bw/day; mg/kg bw/day; mg/kg bw/day), DMEL (Derived Minimum Effect Level) - not included for short–term effects, Insufficient data available (further information necessary), Hazard unknown (no further information necessary), Hazard unknown but no further hazard information necessary as no exposure expected, ‘No DNEL required: short term exposure controlled by conditions for long-term’ is added, Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian), No adverse effect observed (not irritating), Adverse effect observed (irreversible damage), mg/kg bw/day (nominal/actual dose received), See ‘Study results oral: Prioritization by test species’, mg/L air (combining mg/L air, mg/L air (nominal), mg/L air (analytical), mg/m³ air, mg/m³ air (nominal), mg/m³ air (analytical)), ppm (combine ppm, ppm (nominal), ppm (analytical), mg/kg bw/day (actual dose received), mg/kg bw/day (combining mg/kg bw/day (nominal), mg/kg bw/day (actual dose received) and mg/kg bw/day), mg/cm² per day (combining mg/cm² per day, mg/cm² per day (nominal), mg/cm² per day (analytical)), No study available / no study available (further information necessary). - data waving justifications or molar per litre Inventory, registration dossier REACH... 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