Moreover, daily fractions higher than 3 Gy may increase the risk of neurotoxicity, ... A variety of strategies have been tested to improve the local control, such as radiation dose escalation, brachytherapy, radiosensitizers' use, and SRS. Poor performance status at the time of diagnosis of brain metastases was also related to short survival (P = 0.001). Brain metastases are manifestations of primary disease progression and often determine a poor prognosis. A 57% response rate was seen in the combined-modality arm (95% confidence interval [CI], 43% to 69%), and a 22% response rate was seen in the teniposide-alone arm (95% CI, 12% to 34%) (P<.001). Promising results from new approaches such as radiosurgery or stereotactic surgery of brain metastases have recently been reported. To compare 1-year survival and acute toxicity rates between an accelerated hyperfractionated (AH) radiotherapy (1.6 Gy b.i.d.) Although a previous RTOG Phase I/II report had suggested a potential benefit in patients with limited metastatic disease, a good Karnofsky performance status, or neurologic function when treated with an AH regimen, this randomized comparison could not demonstrate any improvement in survival when compared to a conventional regimen of 30 Gy in 10 fractions. Survival and prognostic factors were similar to those found in the literature. On multivariate analysis, improved OS was significantly associated with higher WBRT dose (p = 0.047), Karnofsky Performance Score (KPS) > or = 70 (p = 0.034), less than four brain metastases (p = 0.036), and lack of extracerebral metastases (p = 0.010). A phase III study, A randomized phase III study of accelerated hyperfractionation versus standard in patients with unresected brain metastases: A report of the Radiation Therapy Oncology Group (RTOG) 9104, Essai de phase III randomisé comparant la fotémustine seule ou associée à une irradiation encéphalique dans les métastases cérébrales de mélanome †, A randomized phase III protocol for the evaluation of misonidazole with radiation in the treatment of patients with brain metastasis (RTOG-7916), Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials, Radiosurgery for Single and Multiple Brain Metastases, Zimm S, Wampler GL, Stablein D, Hazra T, Young HFIntracerebral metastases in solid-tumor patients: natural history and results of treatment. One hundred seventy-one patients were eligible: eighty-six in arm A and eighty-five in arm B; none had received prior chemotherapy; seventy-six and seventy-three, respectively, were assessable for response. Of the 779 cases, 773 are dead (99%). Patients and methods: Here we retrospectively evaluated whether chemotherapy re-administration (CT-R) was effective in patients after chemotherapy-induced ILD. These findings, collectively, provide morphological evidence supporting the hypothesis that NOS neurons participate in the mechanisms that match neural activity to cerebral blood flow. In: Sawaya R, editor. A trend was observed for number of metastases (2-3 vs >or=4; P = .07). OS rates at both 6 and 12 months were 0%, 67% and 100%, respectively (p=0.020). Gracia Deanti – 106 followers, 267 following, 4872 Pins | young, dumb, but not broke Whole-Brain Radiotherapy for Brain Metastases: Is the Therapeutic Window Enlarging? The utility and optimal use of chemotherapy and radiosensitizing agents is less clear. All patients had a favorable survival prognosis. 17 October 2020 . Eastern Cooperative Oncology Group score, smoking, and pleural effusion independently affect OS of SCLC patients with BM. Purpose. All other patients had relatively minor differences in observed survival, with a median of 4.2 months. 122 followers, 277 following, 4309 Pins – see what Stupid Cupid (anas6592) found on Pinterest, the home of the world's best ideas. One hundred sixteen eligible patients with metastatic cancer to the brain were randomized to receive either radiotherapy 3000 rad/ 10 fractions (treatment 1) or the same radiotherapy plus metronidazole 6 gm/m 2 (treatment 2). Understanding of the current study metastases had similar survival ( 4.6 and 5.1 months, respectively 37.1 70.4... Do not influence survival [ 4, metastatic brain cancer mediators to defuse political... 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